Fecal Bile Acid Excretion in Patients with Colon Cancer, Colon Polyp and Peptic Ulcer

概要

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Fecal bile acids were analyzed by gas chromatography in 10 patients with colon cancer, 25 patients with colon polyp and 10 patients with peptic ulcer. On admission total bile acid excretion in patients with colon cancer was significantly higher than in patients with peptic ulcer (P<0.01). Also, concentration of cholic acid, chenodeoxychoic acid and primary bile acids in patients with colon cancer were significantly higher than those in patients with peptic ulcer (P<0.05, P<0.025) and in patients with colon polyp (P<0.005). Primary bile acids in patients with colon cancer significantly decreased under ward conditions after admission (P<0.05). Total bile acids in patients with colon cancer decreased after admission though there was no significant difference. It is of considerable interest that the fecal bile acid composition of colon cancer patients was different from that of colon polyp and peptic ulcer patients. Fecal bile acids may be involved in the pathogenesis of colon cancer.
東海大学の論文