慢性期脳血管障害の高齢者患者における認知機能と血清ステロイドホルモンの関連の解析検討

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概要

• 論文の詳細を見る

• Among patients over 70 years of age (43 patients; 25 males and 18 females) with chronic cerebrovascular disease (CVD) who were independent of the activity of daily living (ADL), the basic steroid hormone values in serum [dehydroepiandrosterone sulfate (DHEA-S), testosterone (Test), estradiol (E_2) and cortisol (F)] were measured. On blood sampling, the cognitive function evaluated by the Mini-Mental State Examination (MMSE; full scores of 30) and clinical findings [sex differences, neuroimages of brain MRI, and associated disorders; diabetes mellitus, hypertension, hyperlipidemia and heart disease] were examined. Results of MMSE were divided into Group CI scores below 23 and Group N scores between 24 and 30. Those of neuroimages on films were divided into Group L and S as to the visualized number of lesions of CVD over and below 10, respectively, and into Group W^+ and W^- in terms of the respective presence or absence of diffuse ischemic white matter lesions. In males, the basic hormone level of DHEA-S in Group CI tended to be lower than Group N, but the difference was not significant. The levels of Test, E_2 and F were not significant between Group CI and N. On the other hand, the level of E_2 in females was significantly lower in Group CI (p<0.05). In the comparison of neuroimages, there were no significant differences between Group L and S, and Group W^+ and W^-. In addition, the hormone levels of associated disorders in males evidenced no differences, whereas those in females were significantly higher in Test of patients with hyperlipidemia and in F of patients with heart disease (p<0.05). On the basis of the present study, it is suggested that the evaluation of sex-related steroid hormones in elderly ADL-independent patients with CVD provides important pathophysiologic information on their cognitive function that may lead to the development of useful therapeutic adjuncts in the future.

• 愛知医科大学の論文
• 2004-03-15

著者

• 泉 雅之

  愛知医科大学神経内科学教室

• 岩田 学

  愛知医科大学医学部内科学講座(神経内科)

• 泉 雅之

  愛知医科大学医学部内科学講座(神経内科)

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