血管の力学特性評価のためのファントムの開発とその評価

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The present study aims to develop an artificial pulsatile perfusion system (a phantom) for assessing mechanical properties of an artificial or the isolated human arteries. The system consists of a magnet pump, an inverter, a hand-made valve to produce pulsatile flow, a measurement tank to attach arteries and pressure sensors. The flow rate of the pump was controlled by the inverter with changing the driving frequency from 0 to 55Hz. A hand-made valve was designed to produce a pulsatile flow. An echo-ultrasonograph and a two-channel Doppler ultra-velocimeter were set to measure wall structure and displacement of the silicon and rubber tubes, and the flow velocity of the intramural water with a lycopodium powder, respectively. The peak flow rate corresponding to the contraction phase through the valve was much attenuated compared to the theoretically estimation value, but a pulsatile flow rate curve could be obtained. A pressure, a flow velocity and wall displacement wave forms in the sample tubes could be clearly measured and seemed to be reproducible. The mean values of the pressurestrain elastic modulus, the incremental elastic modulus, the Young modulus and the pulse wave velocity obtained under the peak intramural pressure of 60mmHg were 552kPa, 1860kPa, 1540kPa and 16.6m/s in silicon tube, and 308kPa, 758kPa, 682kPa and 12.4m/s in rubber tube, respectively. These values increased with increasing of the intramural pressure, and agreed with the values reported previously. From the above results it may conclude that the mechanical properties of the artificial or the isolated human arteries can be precisely estimated by using the phantom developed here and the measuring devices with echoultrasonograph and Doppler ultra-velocimeter.
豊橋技術科学大学の論文
2004-03-31

血管の力学特性評価のためのファントムの開発とその評価

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