プロプラノロールの光安定性

概要

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An 'one dose package system' has become popular for convenience of the patient. But the quality of drugs and the measurement of their photostabilities are renounced by this system. Propranolol, a β-adrenoreceptor blocking agent, is widely used for angina pectoris, arrhythmia, and hypertension. In this paper, propranolol in the various forms was exposed to light, and the change of the qualification of pharmaceutical preparation of propranolol was studied by their appearance and the TLC analyses. As a result, propranolol was decomposed time-dependently by exposing the light. Additionally, three photodegraded products of propranolol (1) (l-naphthol (2), N-acetylpropranolol (3), and N-formylpropranolol (4)) were isolated and their structures were determined by spectroscopic methods. The results indicated the warning that drugs which are unstable towards light should be carefully handled to protect.
東北薬科大学の論文