Relationship between an Angiotensinogen Gene Polymorphism (M235T) and Serum Lipids: A Cross-Sectional Study among Japanese Workers

スポンサーリンク

概要

• 論文の詳細を見る

• Angiotensinogen (AGT) is a component of the renin-angiotensin system, which plays a central role in blood pressure regulation. Although it is controversial, the association between AGT gene polymorphisms and hypertension, and coronary heart disease is suspected. In a case-control study on the metabolic syndrome, an association between AGT M235T polymorphism and serum total cholesterol (TC) level was demonstrated by Thomas et al. (2001). To reconfirm this relationship, a cross-sectional study among Japanese workers with 876 dyslipidemia and 1,158 non-dyslipidemia subjects was carried out. To evaluate the AGT M235T polymorphism, a PCR-mutant allele specific amplification (MASA) method was employed. No significant difference in the distribution of genetic variance was observed between the two groups. Although it was not significant, the T allele correlating to the lower TC of the present study occurred in a reversed manner to the previous report. In our results, no significant association between AGT M235T and TC was observed.

• 鳥取大学の論文

著者

• Kaetsu Akihiko

  Division Of Environmental And Preventive Medicine And *division Of Health Administration And Promoti

関連論文

• An outbreak of measles in Saitama City in 2007. What is the vaccination strategy to eliminate measles in Japan?
• The Lack of Relationship between an Endothelin-1 Gene Polymorphism (Ala288Ser) and Incidence of Hypertension : A Retrospective Cohort Study among Japanese Workers
• Retrospective Cohort Study of Smoking and Lung Cancer Incidence in Rural Prefecture, Japan
• Relationship between an Angiotensinogen Gene Polymorphism (M235T) and Serum Lipids: A Cross-Sectional Study among Japanese Workers

スポンサーリンク