The Lack of Relationship between an Endothelin-1 Gene Polymorphism (Ala288Ser) and Incidence of Hypertension : A Retrospective Cohort Study among Japanese Workers
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概要
- 論文の詳細を見る
BACKGROUND: Some case-control association studies revealed the relationship between some endothelin-1 (ET-1) gene polymorphisms and blood pressure. Because no report was available about the relationship between any ET-1 gene polymorphism and incidence of hypertension, we examined the relationship between novel ET-1 gene polymorphism (G862T / Ala288Ser in exon 5) and incidence of hypertension by a retrospective cohort study.METHODS: The subjects were Japanese workers at a company in Shimane Prefecture in Japan. The polymorphism with genome DNA extracted from the blood of the workers was analyzed using the polymerase chain reaction confronting two pair primers method. According to the results of two regular health checkups with a 6-year interval, the study population was divided into two groups by blood pressure and antihypertensive treatment in 1998, after excluding people who had hypertension in 1992.RESULTS: There were 133 (93 males and 40 females) incidences of hypertension observed among the study population of 922 (540 males and 382 females). In the univariate analysis, odds ratios of Ala/Ser and Ser/Ser against Ala/Ala were 0.98 (95% confidence interval [CI]): 0.7-1.4) and 0.79 (95% CI: 0.4-1.6), respectively. In the multivariate analysis adjusted for sex, age, body mass index, serum total cholesterol, fasting blood sugar, and smoking and drinking habits, odds ratios for Ala/Ser and Ser/Ser against Ala/Ala were 0.97 (95% CI: 0.7-1.4) and 0.75 (95% CI: 0.4-1.5), respectively.CONCLUSIONS: The ET-1 gene polymorphism in this study did not seem to be associated with the incidence of hypertension among the Japanese workers.
- 日本疫学会の論文
著者
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OSAKI YONEATSU
Division of Environmental and Preventive Medicine, Faculty of Medicine, Tottori University
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KISHIMOTO TAKUJI
Division of Environmental and Preventive Medicine, Faculty of Medicine, Tottori University
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Kaetsu Akihiko
Division Of Health Promotion Department Of Health Bureau Of Health And Welfare Saitama City Governme
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Kaetsu Akihiko
Division Of Environmental And Preventive Medicine Department Of Social Medicine Faculty Of Medicine
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Kaetsu Akihiko
Division Of Environmental And Preventive Medicine And *division Of Health Administration And Promoti
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Kurozawa Youichi
Department Of Public Health Faculty Of Medicine Tottori University
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Okamoto Mikizo
Division Of Environmental And Preventive Medicine Department Of Social Medicine Faculty Of Medicine
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Osaki Yoneatsu
Division Of Environmental And Preventive Medicine Department Of Social Medicine Faculty Of Medicine
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Osaki Y
Division Of Environmental And Preventive Medicine Department Of Social Medicine Tottori University F
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Kurozawa Yoichi
Division Of Health Administration And Promotion Faculty Of Medicine Tottori University
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OKAMOTO Mikizoh
Division of Environmental and Preventive Medicine, Faculty of Medicine, Tottori University
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FUKUMOTO Soji
Division of Molecular Medical Zoology, Faculty of Medicine, Tottori University
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Kishimoto Takuji
Division Of Environmental And Preventive Medicine Department Of Social Medicine Faculty Of Medicine
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Kishimoto Takuji
Division Of Environmental And Preventive Medicine Faculty Of Medicine Tottori University
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Fukumoto Soji
Division Of Molecular Medical Zoology Faculty Of Medicine Tottori University
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