<原著>糖尿病性細小血管合併症と血中アルドース還元酵素蛋白量および肝細胞増殖因子
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To clarify the relationship between blood aldose reductase (AR) level and hepatocyte growth factor (HGF) of diabetic microangiopathy, correlations between blood AR levels and HbA1c, serum lipid, mean blood pressure and an annual change were examined. AR levels were correlated with morbidity rates of diabetic microangiopathy. Serum HGF were measured of type 2 DM. Correlations between mean blood pressure, HbA1c and stage of diabetic retinopathy, nephropathy and neuropathy were examined. AR/Hb (Measured AR level was divided by hemoglobin level) was not affected by time, blood glucose control, or serum lipid. Patients with estimated duration < 10 years did not have retinopathy, nephropathy, or neuropathy when AR/Hb was < 8 ng/mgHb. However in patients with AR/Hb of ≧ 8 ng/mgHb, higher AR/Hb levels tended to result in higher incidences of each complication. In the group with HbA1c below 8 %, patients with AR/Hb ≧ 10 ng/mgHb developed retinopathy, nephropathy, and neuropathy even if their estimated duration of diabetes was < 10 years. It is suggested that AR levels are specific to each patient and are an independent risk factor of diabetic microangiopathy irrespective of blood glucose level; individual differences of AR levels are likely to influence the development of diabetic complications. Correlations between mean blood pressure, HbA1c and serum HGF were not admitted. Also between stage of diabetic microangiopathy and serum HGF were not admitted. This data suggests that measuring the AR level is significant for considering risks of developing of diabetic microangiopathy, but measuring the serum HGF level is not useful in diabetic microangiopathy.
- 新潟大学の論文
- 2003-02-10
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- 糖尿病性細小血管合併症と血中アルドース還元酵素蛋白量および肝細胞増殖因子