1) 冠動脈に対する intervention (<シンポジウム> 成人心臓血管治療の最前線 : Intervention と外科治療)

概要

論文の詳細を見る
Percutaneous transluminal coronary angioplasty (PTCA) for coronary artery disease was intro-duced in 1977, in this strategy a catheter-borne balloon was inflated at the point of coronary stenosis. Alternative mechanical devices have been developed and have included rotating blades (DCA) or burrs (rotablator), lasers to achieve ablation of lesions and metal intra-coronary stent. The advantages of PTCA are many and include a low level of procedure-related morbidity, a low proce-dure-related mortality rate and short hospital stay, early return to activity. The disadvantages of PTCA were the risk of acute coronary occlusion and a significant incidence of restenosis (30 % to 40 % in case of balloon angioplasty). The advent of intracoronary stents and improved pharmacologic therapies have greatly decreased the risk of acute coronary occlusion and the incidence of restenosis (20 % to 25 % in case of stents). In-stent restenosis is a new problem. New strategies are tried to reduce the restenosis and have included intra-vascular radiation therapy, intra-vascular sonotherpy and local drug delivery.
新潟大学の論文
2003-02-10