<原著>腎移植における拒絶反応と血中に存在する抗血管内皮細胞抗体との関連性

概要

論文の詳細を見る
Vascular endothelial cells (ECs) are considered to be a primary target for injury in allograft rejection. However, the relationship between serum antibody activity to ECs and rejection episodes has not been extensively examined in renal transplantation. 22 renal transplant recipients were included in this study, serum antibody activity to vascular endothelial cells (AECA) was measured using a cellular enzyme-linked immunosorbent assay (ELISA) in which human umbilical vein endothelial cells (HUVEC), human glomerular endothelial cells (HGEC) and human dermal microvascular endothelial cells (MvE) were preincubated with TNF-α and used as target cells. Serum samples were obtained just before transplantation and once a week during the immediate 1-3 month posttranspantation period. There was a significant correlation between the presence of AECA against HGEC and rejection episodes (P<0.05). Patients with multiepisodes of rejection showed significantly higher frequencies of AECA than patients with monoepisodic rejection (p<0.0005). It should be noted that patients suffering from multiepisodes of rejection revealed higher AECA titers before transplantation. These findings imply that the HGEC-ELISA could be used as a prospective, informative test to identify patients with a higher risk of acute rejection in renal transplantation.
新潟大学の論文
2002-03-10