海綿骨欠損内の骨梁構造形成に及ぼす周囲環境因子の影響(S02-2 生体組織のマルチスコープメカニクス(2).微細構造とメカニクス,S02 生体組織のマルチスコープメカニクス)

概要

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Mechanical and biological factors affect regeneration process of trabecular bone structure in cancellous bone defects. Basic understanding of these factors will help us in designing artificial joints and implants and scaffold microstructure for bone tissue regeneration. In this study, artificial defect was created in cancellous bone region of a rat distal femur, and a formation process of trabecular structure in the defect was evaluated using X-ray μCT images in terms of a relation with mechanical and biological factors. As a result of experiment using a pin with a slit of three different shapes, it was shown that mechanical factors may not direct influence the early stage of trabecular bone regeneration, but biological factor may have remarkable influence on the process.
一般社団法人日本機械学会の論文
2004-09-04