Cardioprotective Activity of Alcoholic Extract of Tinospora cordifolia in Ischemia-Reperfusion Induced Myocardial Infarction in Rats(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• It has been suggested that the beneficial effects of reperfusing the myocardium might be in part reversed by the occurrence of reperfusion injury. Oxidative stress was suggested to be implicating in the pathogenesis of ischemia-reperfusion (I/R) injury. Many antioxidative plants were shown to be cardioprotective in experimental models of myocardial ischemia-reperfusion (I/R) injury. The present study was designed to investigate the effects of pretreatment with alcoholic extract of Tinospora cordifolia in an in vivo rat model. The model adopted was that of surgically-induced myocardial ischemia, performed by means of left anterior descending coronary artery occlusion (LAD) for 30 min followed by reperfusion for another 4h. Infarct size was measured by using the staining agent TTC (2, 3, 5-triphenyl tetrazolium chloride). Lipid peroxide levels in serum and in heart tissue were estimated spectrophotometrically by the methods developed by Yagi and Ohkawa et al. respectively. A lead II electrocardiogram was monitored at various intervals throughout the experiment. A dose dependent reduction in infarct size and in lipid peroxide levels of serum and heart tissue were observed with the prior treatment of T. cordifolia with various doses for 7d compared to control animals. Hence, the present study suggests the cardioprotective activity of T. cordifolia in limiting ischemia-reperfusion induced myocardial infarction.

• 公益社団法人日本薬学会の論文
• 2005-12-01

著者

• Viswanath Routhu

  Pharmacology Division Department Of Pharmaceutical Sciences Andhra University

• Kumar Veeravalli

  Pharmacology Division Department Of Pharmaceutical Sciences Andhra University

• RAO Pragada

  Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University

• SUBBARAJU Gottumukkala

  Liala Impex, DSIR Recognized R&D Center

• Subbaraju Gottumukkala

  Liala Impex Dsir Recognized R&d Center

• Rao Pragada

  Pharmacology Division Department Of Pharmaceutical Sciences Andhra University

• Rao Pragada

  Pharmacology Div. Dep. Of Pharmaceutical Sciences Andhra Univ.

関連論文

• Cardioprotective Activity of Alcoholic Extract of Tinospora cordifolia in Ischemia-Reperfusion Induced Myocardial Infarction in Rats(Pharmacology)
• Anti-inflammatory Activity of a New Sphingosine Derivative and Cembrenoid Diterpene (Lobohedleolide) Isolated from Marine Soft Corals of Sinularia crassa TIXIER-DURIVAULT and Lobophytum species of the Andaman and Nicobar Islands(Pharmacology)

スポンサーリンク