Anti-inflammatory Activity of a New Sphingosine Derivative and Cembrenoid Diterpene (Lobohedleolide) Isolated from Marine Soft Corals of Sinularia crassa TIXIER-DURIVAULT and Lobophytum species of the Andaman and Nicobar Islands(Pharmacology)

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概要

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• The aim of this study is to determine the anti-inflammatory activity of a new sphingosine derivative (1) and cembrenoid diterpene (lobohedleolide)(2) isolated from the soft corals of Sinularia crassa and Lobophytum species respectively, collected on the coasts of Andaman and Nicobar Islands. The anti-inflammatory activity was evaluated using carrageenin-induced rat hind paw edema model for acute inflammation and cotton pellet granuloma model for chronic inflammation. Indomethacin was used as a standard drug in this study. Both the sphingosine derivative (1) and the cembrenoid diterpene (2) produced the maximum effect at a dose of 10mg/kg and this is comparable to that of indomethacin (2mg/kg, p<0.001). The observed anti-inflammatory activity is almost identical in both the types of experimental inflammation.

• 公益社団法人日本薬学会の論文
• 2005-07-01

著者

• Rao Nalamolu

  Pharmacology Division Gitam Dental College

• RAO Pragada

  Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University

• RADHIKA Parvataneni

  Medicinal Chemistry, Andhra University

• ARCHANA Jorige

  Pharmacology Divisions, University College of Pharmaceutical Sciences, Andhra University

• Rao Pragada

  Pharmacology Division Department Of Pharmaceutical Sciences Andhra University

• Rao Pragada

  Pharmacology Divisions University College Of Pharmaceutical Sciences Andhra University

• Archana Jorige

  Pharmacology Divisions University College Of Pharmaceutical Sciences Andhra University

• Radhika Parvataneni

  Medicinal Chemistry Andhra University

• Rao Pragada

  Pharmacology Div. Dep. Of Pharmaceutical Sciences Andhra Univ.

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• Anti-inflammatory Activity of a New Sphingosine Derivative and Cembrenoid Diterpene (Lobohedleolide) Isolated from Marine Soft Corals of Sinularia crassa TIXIER-DURIVAULT and Lobophytum species of the Andaman and Nicobar Islands(Pharmacology)

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