The Influence of Radiation Quality on Radiation-induced Hemolysis and Hemoglobin Oxidation of Human Erythrocytes

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概要

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• Human erythrocytes were exposed to γ-rays and α-particles to assess radiation-induced membrane damage and hemoglobin oxidation and denaturation. With all parameters measured, the α-particles proved to be less efficient than the γ-rays. The time-dependence of hemolysis showed also clear differences : with the γ-rays the process was faster, reaching saturation after 40-90min (depending on dose), but with the α-particles the final level was attained only after about 3-7 h. Hemoglobin oxidation and denaturation could be measured only after γ-exposure, but they were negligible with the α-particles when comparable doses were applied. These results are interpreted by proposing that OH-radicals, whose yields are smaller with densely ionizing radiation, play a crucial role in the induction of the processes for radiation-induced erythrocyte damage.

• 日本放射線影響学会の論文
• 2004-06-15

著者

• Kiefer Juegen

  Strahlenzentrum Der Justus-liebig-universitat

• PUCHALA Mieczyslaw

  Department of Molecular Biophysics, University of Lodz

• SZWEDA LEWANDOWSKA

  Department of Molecular Biophysics, University of Lodz

• Szweda Lewandowska

  Department Of Molecular Biophysics University Of Lodz

• Szweda-lewandowska Zofia

  Department Of Molecular Biophysics University Of Lodz

• Puchala Mieczyslaw

  Department Of Molecular Biophysics University Of Lodz

関連論文

• The Influence of Radiation Quality on Radiation-induced Hemolysis and Hemoglobin Oxidation of Human Erythrocytes
• The Influence of Split Doses of γ-Radiation on Human Erythrocytes

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