The Influence of Split Doses of γ-Radiation on Human Erythrocytes

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概要

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• Human erythrocyte suspensions in an isotonic Na-phosphate buffer, pH 7.4, of hematocrit of 2% were exposed under air to gamma radiation at a dose rate of 2.2 kGy. Erythrocytes were irradiated with single doses, and identical doses split into two fractions with an interval time of 3.5 h between following exposures. The obtained results indicated that the irradiation of enucleated human erythrocytes with split doses caused a reduction of hemolysis (2.4 times), a decrease in the level of damage to membrane lipids and the contents of MetHb, compared with identical single doses. However, the splitting of radiation doses did not change the level of damage to the membrane proteins, as was estimated with a maleimide spin label. The obtained results suggest that a decrease in the level of damage to lipids was related to a decrease in hemolysis.

• 日本放射線影響学会の論文
• 2003-09-00

著者

• Szweda-lewandowska Zofia

  Department Of Molecular Biophysics University Of Lodz

• SZWEDA-LEWANDOWSKA ZOFIA

  Department of Molecular Biophysics, University of Lodz

• Koziczak Renata

  Department of Molecular Biophysics, University of Lodz

• Gonciarz Marta

  Department of Molecular Biophysics, University of Lodz

• Krokosz Anita

  Department of Molecular Biophysics, University of Lodz

関連論文

• The Influence of Radiation Quality on Radiation-induced Hemolysis and Hemoglobin Oxidation of Human Erythrocytes
• The Influence of Split Doses of γ-Radiation on Human Erythrocytes

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