Enhancement of Radiation-induced Apoptosis by Preirradiation with Low-dose X-rays in Human Leukemia MOLT-4 Cells
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概要
- 論文の詳細を見る
The effects of low-dose preirradiation on the process of radiation-induced cell death were investigated in human leukemic MOLT-4 cells. By 0.2 Gy of X-rays given 12 h prior to a challenge dose of 5 Gy, the process of apoptosis was accelerated. The acceleration was associated with a certain increase in caspase 3 activity, a disruption of the mitochondrial transmembrane potential, and an accumulation of p53 proteins. This finding is in contrast to the radiation adaptive responses in which a small dose of preirradiation would induce certain radiation resistance and decrease the cell death after irradiation with higher doses.
- 日本放射線影響学会の論文
- 2004-06-15
著者
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SAKAI Kazuo
Low Dose Radiat. Res. Center, Centl. Res. Inst. Electric Power Industry
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Sakai Kazuo
Low Dose Radiat. Res. Center Centl. Res. Inst. Electric Power Industry
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CHEN Zhiyun
Low Dose Radiat. Res. Center, Centl. Res. Inst. Electric Power Industry.
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Chen Zhiyun
Low Dose Radiation Research Center Central Research Institute Of Electric Power Industry
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Chen Zhiyun
Low Dose Radiat. Res. Center Centl. Res. Inst. Electric Power Industry.
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Sakai Kazuo
Low Dose Rad. Res. Center Centl. Res. Inst. Electric Power Industry
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Sakai Kazuo
Low Dose Radiation Research Center Central Research Institute Of Electric Power Industry:(present Ad
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