膀胱腫瘍組織内遊離基の研究 : 第3報 腫瘍周囲粘膜のESRによる検討
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The high concentrated level of ^<14>N-hfs in tissues of transitional cell carcinoma has been published as a part of series of present study, in which the ESR spectra from the cancer tissues were compared with normal mucosa of the urinary bladder taken from the area distant from the tumor or different individuals without badder tumor. In the present paper, the tumor surrounding mucosa, 1.0 cm in width and grossly normal was studied with ESR on 4 cases and the results were compared with those of tumors and distant areas. It was revealed that the tumor surrounding mucosa containing a high level of ^<14>N-hfs on ESR spectra in all cases studied. The materials with ^<14>N-hfs signals had concealed the foci of abnormally proliferating cells in 6 to 17% of all the serial sections studied histologically. In some cases, the degrees of ^<14>N-hfs signals remained in high level as if that of tumor itself though the decreased levels of malignancies which represented by histology on the tumor surrounding mucosa. Actually the signals of ^<14>N-hfs were larger than that of tumor itself in the distant area of the first case, and same level in the tumor surrounding mucosa of the third case, while they decreased down 60-70% in another materials with ^<14>N-hfs. In the forth case, however, the signals of ^<14>N-hfs were not recognized in tumor itself as one of exceptions in the previous paper but the signals were recorded in the tumor surrounding tissues. The results suggest that the appearance of ^<14>N-hfs is related with the activity of tumor proliferation rather than the existence of tumors, however, the amount of ^<14>N-hfs may or may not relate with histological findings. A complete chemical analysis of ^<14>N-hfs will be extremely difficult or almost impossible by the methods available at the present time. Therefore the analytical method used in the present paper, if a large series of cases were studied with blind tests, would be a useful way to identify a precancerous lesions in clinical medicine.
- 社団法人日本泌尿器科学会の論文
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