腎移植の研究 : III 同種腎移植における血清蛋白の変動 : B ヒトおよびイヌの同種腎移植の拒否反応時における血清蛋白の変動

概要

論文の詳細を見る
The changes of serum protein fractions in renal homotransplantation were studied specially in relation to rejection. The protein fractions were measured in canine renal homotransplantation combined with or without steroid therapy. Renal autotransplantation and nephrectomized cases were studied as controls. The protein fractions were measured in 5 clinical cases of renal homotransplantation. Serum protein fractions were measured by paper electrophoresis and further the subfractions were measured by antibody absorption method. 1) Serum α_2-globulin was increased after renal homotransplantation, however similar change was also noticed in renal autotransplantation, therefore it is not considered as specific to renal homotransplantation. 2) The increase of α_2-lipoprotein at rejection after renal homotransplantation was characteristic. It was not noticed in renal autotransplantation. Other protein subfractions tend to decrease at rejection, specially the decrease of Ig-M was characteristic. 3) The changing pattern of protein subfractions at initial rejection and late rejection was similar, however the changes at initial rejection was acute and intensive and the changes at late rejection was chronic and mild and then it became gradually irreversible. 4) The follow up of Ig-M is an excellent method for diagnosis of rejection and for prognosis of renal transplantation. 5) Discussions were given about the relation between serum lipoprotein and isoantigen, and the problem of complement and immunoglobulin in renal homotransplantation. 6) The changes of serum protein at rejection was compared with the changes of serum protein caused by immunosuppression, renal insufficiency and autoimmune diseases.
社団法人日本泌尿器科学会の論文

腎移植の研究 : III 同種腎移植における血清蛋白の変動 : B ヒトおよびイヌの同種腎移植の拒否反応時における血清蛋白の変動

スポンサーリンク

概要

著者

関連論文

スポンサーリンク