磁界計測による神経線維直径分布の推定に関するシミュレーション解析

概要

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Electric stimulation of a peripheral nerve generates a magnetic field produced by action currents within nerve fibers. The conduction characteristics of these action currents of the nerve affect the magnetic field produced, which also reflects the characteristics of each bundle of fibers, though these consist of thousands of nerve fibers. Therefore, a method to estimate the distribution of the diameters of nerve fibers was investigated. A nerve was modeled as a bundle of nerve fibers of different diameters. Then stimulation of the bundle and the generation of a magnetic field around it were attempted. Stimulation of the bundle at two points with different intensities makes it possible to activate only the low-threshold nerve fibers within the bundle. This method was applied to estimate the distribution of the diameters of nerve fibers from magnetic field measurements. To obtain the distribution of the diameters of nerve fibers with relatively high estimation accuracy, using the peak position analysis of a magnetic field was suggested.
社団法人日本生体医工学会の論文
2004-12-10