高頻度間欠的振動換気の生体におけるガス輸送効率の評価

概要

論文の詳細を見る
The efficiency of axial gas dispersion during ventilation with high-frequency oscillation (HFO) is improved by manipulating the oscillatory flow waveform so that intermittent oscillatory flow occurs. We therefore measured the arterial CO_2 pressure and expired CO_2 concentration during high-frequency intermittent oscillatory flow in rabbits to verify the intermittency augmentation effect on gas exchange. In this work, the oscillatory frequency was fixed at 15 Hz so as to apply the results to a HFO respirator. Tidal volume was varied from 2.0 to 3.0 mL/kg. The waveform of the intermittent oscillatory flow was set using an intermittent parameter, τ=0.5, where τ represents the ratio of the advection to the oscillation period. When tidal volume was small, the arterial CO_2 pressure was dependent on the flow patterns and decreased when using intermittent oscillatory flow. It was also found that the expired CO_2 concentration becomes greater than that in sinusoidal oscillatory flow. In addition, the use of intermittent oscillatory flow effectively augments gas exchange for ventilation in surfactant deficient rabbits.
社団法人日本生体医工学会の論文
2004-12-10