Upregulation of RHAMM mRNA Expression by Interleukin 1β and Tumor Necrosis Factor α in Cultured Rabbit Articular Chondrocytes

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概要

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• We investigated the effects of interleukin-1β(IL-1β)and tumor necrosis factor α(TNF-α)on receptor for hyaluronic acid-mediated motility(RHAMM)mRNA expression in polylayer culture of rabbit articular chondrocytes using reverse transcription-polymerase chain reaction(RT-PCR). The RHAMM mRNA expression was significantly increased at the concentration of 1 ng / mL and 10 ng / mL of IL-1β and 10 ng / mL of TNF-α. These results suggest that RHAMM may increase in articular chondrocyte under the conditions of inflammatory joint diseases, such as osteoarthritis and rheumatoid arthritis.

• 日本結合組織学会の論文
• 1999-03-25

著者

• Mizusawa Noriko

  Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Gra

• HORIUCHI Saburo

  Department of Biochemistry, Iwate Medical University

• Mizusawa Noriko

  Department Of Biochemistry Iwate Medical University

• TAJIMA Ikuro

  Department of Orthopedic Surgery

• ENDO Koujiro

  Department of Orthopedic Surgery, Iwate Medical University

• Horiuchi S

  Iwate Medical Univ. Morioka

• Horiuchi Saburo

  Department Of Biochemistry Iwate Medical University

• Endo Koujiro

  Department Of Orthopedic Surgery Iwate Medical University

• Tajima Ikuro

  Department Of Orthopedic Surgery:department Of Biochemistry Iwate Medical University

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