膜型マトリックスメタロプロテアーゼ

概要

論文の詳細を見る
Matrix metalloproteinases(MMPs)regulate formation and remodeling of tissue by degrading extracellular matrix(ECM). At least 18 MMPs(MMP family)were identified and the number is still increasing. Four of them are membrane-type MMPs(MT-MMPs)that have a transmembrane domain and a short cytoplasmic tail. Although MT4-MMP has not been identified yet, recombinant MT1-, MT2- and MT3-MMP showed activity against some ECM components and also induced specific activation of pro-gelatinase A which has been reported to be activated uniquely by a cell surface activator. Compared to the soluble-type MMPs, cell surface MMPs are responsible for limited ECM degradation at the periphery of cells, which is thought to be important for regulation of the functions of cells in tissue, such as proliferation, apoptosis, morphogenesis, motility and invasion etc.
1998-12-25