Genetic Basis of Collagen Diseases in MRL Mice with a Deficit in Fas-mediated Apoptosis:Dissection of the complex pathological manifestations

スポンサーリンク

概要

• 論文の詳細を見る

• The lpr and the gld gene are a Fas deletion mutant and a Fas ligand(Fas-L)mutant, respectively. These genes induce a deficit in Fas-mediated apoptosis of activated T and B cells and macrophages in a result of an incapacity for Fas / Fas-L interaction, and have been thought to generate subsequently autoimmune disease. An MRL / MpJ-lpr / lpr(MRL / lpr)strain develop various forms of collagen disease, including polyarteritis, glomerulonephritis(GN), sialoadenitis and arthritis, associated with autoimmune traits. A newly established MRL recombinant congenic strain of mice bearing the gld gene, MRL / MpTn-gld / gld(MRL / gld), also developed similar diseases as those in MRL / lpr mice. The treatment of MRL / gld mice with anti-Fas antibodies was successful in the prevention and amelioration of these diseases. These findings might indicate that collagen diseases in these mice are a single gene disease, associated with the complex pathological manifestations as pleiotropy. However, comparative studies with C3H / HeJ and C57BL / 6J strains bearing lpr or gld revealed that these diseases developed only in mice with an MRL background. Moreover, the complex pathological manifestations of collagen diseases were genetically segregated among MRL / lpr x(MRL / lpr x C3H / lpr)F1 mice. This indicates that an MRL genetic background has particular susceptible gene(s)for the development of each disease. Several MRL recombinant congenic strains of mice derived from the hybrid mice between MRL / lpr and C3H / lpr strains, were established, one of which McH5-lpr / lpr(McH5 / lpr)developed only polyarteritis, but not glomerulonephritis, arthritis and sialoadenitis. In the association studies of each disease with polymorphic microsatellite markers using the backcross mice, furthermore, responsible gene loci for arteritis were mapped on chromosomes 3 and 4. These loci were not associated with other collagen diseases. Thus, it is likely that complex pathological manifestations of collagen diseases are under the control of different combinations of host polygenes.

• 日本結合組織学会の論文
• 1998-12-25

著者

• NOSE Masato

  Department of Pathogenomics, Ehime University Graduate School of Medicine

• Nose Masato

  Dept. Pathology Ehime University School Of Medicine

• Nose Masato

  Department Of Pathology Tohoku University School Of Medicine

• Nose Masato

  Department Of Internal Medicine Division Of Nephrology And Rheumatology Aichi Medical University Sch

• Nose Masato

  Ehime University School Of Medicine Department Of Pathology

関連論文

• Renal pathology of ANCA-related vasculitis : proposal for standardization of pathological diagnosis in Japan
• Kyoto Rhino Rats Derived by ENU Mutagenesis Undergo Congenital Hair Loss and Exhibit Focal Glomerulosclerosis
• Enhancement of ectopic bone formation in mice with a deficit in Fas-mediated apoptosis
• Expression of Phaseolus vulgaris leukoagglutinin-binding oligosaccharides in oral squamous cell carcinoma : Possible association with the metastatic potential
• Aberrant expression of IRF-1 gene for the treatment of arthritic lesions in MRL/lpr mice
• Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice
• Deoxyspergualin, an immunosuppressant, in patients suffering from nephropathies with crescent formation : an open-label trial to evaluate safety and efficacy
• Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats : Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene
• Atypical hyperplasia of choledocho-pancreatic duct epithelium in an Otsuka Long Evans Tokushima Fatty strain of rats
• OE-043 Osteopontin and C-reactive Protein Co-localize in Atherosclerotic Plaques(Atherosclerosis, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Suppression of experimental lupus nephritis by aberrant expression of the soluble E-selectin gene
• Spontaneous occurrence of chronic non-suppurative destructive cholangitis and antimitochondrial autoantibodies in MRL/lpr mice : Possible animal model for primary biliary cirrhosis
• An Asian case of fibroblastic rheumatism : clinical, radiological, and histological features
• Toll-Like Receptor 3 Signaling Induces Chronic Pancreatitis through the Fas/Fas Ligand-Mediated Cytotoxicity
• Augmentation of osteopontin expression in renal tubuli is independent of a histopathological type of glomerular lesions in mouse lupus nephritis
• Pleomorphic Carcinoma of the Lung Associated with Loss of Heterozygosity of p53 Gene
• Histopathological characteristics of early rheumatoid arthritis: a case one month after clinical onset
• Munchausen syndrome with foreign-body granuloma mimicking rheumatic diseases
• Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System
• Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720
• Genetic Basis of Collagen Diseases in MRL Mice with a Deficit in Fas-mediated Apoptosis:Dissection of the complex pathological manifestations
• Novel recombinant congenic mouse strain developing arthritis with enthesopathy
• Aneurysms of the renal arteries associated with segmental arterial mediolysis in a case of polyarteritis nodosa
• A Proposal Concept of a Polygene Network in Systemic Vasculitis : Lessons from MRL Mouse Models
• Bone marrow cell transfer of autoimmune diseases in a MRL strain of mice with a deficit in functional Fas ligand: Dissociation of arteritis from glomerulonephritis
• Increased expression of soluble form of vascular cell adhesion molecule-1 aggravates autoimmune arthritis in MRL-Fas^ mice
• Annual dynamics of marine birnavirus (MABV) in cultured Japanese flounder Paralichthys olivaceus and sea water
• Regulatory Factors on Immunocytolysis of Cardiac Cells and Mesenchymal Cells
• Do Mucosal Mast Cells Contribute to the Immediate Asthma Response?
• Genetic heterogeneity in rheumatoid arthritis mouse models induced by extrinsic and intrinsic factors
• ENUミュータジェネシス由来のKyoto rhinoラットは先天性脱毛と巣状糸球体硬化症を示す
• Buerger's disease manifesting nodular erythema with livedo reticularis
• Plasma thrombin-cleaved osteopontin elevation after carotid artery stenting in symptomatic ischemic stroke patients

もっと見る 閉じる

スポンサーリンク