インテグリンとシグナル伝達機構

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Integrins mediate a wide variety of biological processes by functioning as receptors and transmembrane transducers in cell adhesion, migration, and signal transduction events. In this literature, the molecular aspects between integrin function and signal transduction would be reviewed including integrin signal trasduction, the collaboration of integrin function with growth factor signalings, the regulation of integrin function mediated by small GTP-binding proteins, the association of cytoskeletal and signaling molecules. Tensin and FAK(Focal Adhesion Kinase)play central roles in integrin signal transduction through the molecular hierarchies of cytoskeletal and signaling molecules. In the collaboration or synergy between integrins and growth factors involving MAP(Mitogen Activated Protein)kinases, integrin aggregation and occupancy are required, providing opportunities for collaboration between these major regulatory systems. Rho, Rac, Cdc42 are three Ras-related GTP-bnding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. R-Ras and H-Ras also participate in the regulation of integrin function. On the other hand, FAK can induce the accumulation of various cytoskeletal and signaling molecules, and other cytoskeletal molecules including tensin, vinculin, and paxillin are involved in the signaling events. Integrins, therefore, mediate a transmembrane hierarchies of molecular responses through the huge network of cytoskeletal and signaling molecules.
日本結合組織学会の論文
1998-09-25

インテグリンとシグナル伝達機構

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