Inhalation of Diesel Exhaust for Twelve months Retarded the Increase in Bone Mass in Rats

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概要

• 論文の詳細を見る

• Experiments were conducted to determine the affects of diesel exhaust on bone mass and mechanical strength in rats after continuous exposure to diesel exhaust for 12 months. The rats were assigned to three groups: those exposed to total diesel engine exhaust with 5.63 mg / m^3 particulate matter, 4.10ppm nitrogen dioxide, 8.10ppm nitrogen monoxide; those exposed to filtered exhaust without particulate matter; and those exposed to clean air. The bone mineral content(BMC), bone mineral density(BMD)values in the lumbar vertebrae and BMD of the total femur were significantly retarded in the total exhaust group compared with the other two groups. The femur length was significantly shorter and the breaking strength was weaker in the total exhaust group. Microradiographs showed that the transverse connections of cancellous bone partly disappeared in the lumbar vertebrae and femur in the total exhaust group. Bone metabolic makers in serum and urine did not show any significant differences among the groups. These findings suggest that the ling-term inhalation of diesel exhaust disturbs the increase in bone mass, and couses structural changes and fragile bones.

• 日本結合組織学会の論文
• 1998-09-25

著者

• Watanabe Nobue

  Department of Environmental Health, Tokyo Metropolitan Public Health Research Institute

• Watanabe Nobue

  Department Of Environmental Health Tokyo Metropolitan Research Laboratory Of Public Health

関連論文

• Transfer of Polycyclic Aromatic Hydrocarbons to Fetuses and Breast Milk of Rats Exposed to Diesel Exhaust
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• Urinary 17-KS and 17-OHCS as Markers of Endocrine Disruption by Air Pollution in Primary School Children
• Inhalation of Diesel Exhaust for Twelve months Retarded the Increase in Bone Mass in Rats

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