重篤度が異なる患者から分離されたデングウィルスに対する由来の異なるネッタイシカマ集団の感受性

概要

論文の詳細を見る
The capacity for oral infection and dissemination of two dengue type-2 viruses, ThNH7/93 and ThNHpll/93, isolated from patients exhibiting different disease severity, dengue shock syndrome (DSS) and classical dengue fever (DF), respectively, was compared in two strains of Aedes aegypti from different geographic origin. The capacity for oral infection and dissemination to the head tissues of the isolate ThNH7/93 (DSS) was significantly higher in the Ae. aegypti strain from Nakhon Phanom, Thailand, than that in the strain from Escuintla, Guatemala, (P<0.05, x^2=6.833, df=1), whereas for the isolate ThNHpll/93 (DF) the capacity was not significantly different between the Ae. aegypti strains (P>0.05, x^2=0.557, df= 1). The Ae. aegypti strain from the location where the viruses were isolated (Nakhon Phanom, Thailand) showed significantly higher susceptibility to the isolate ThNH7/93 strain than to the isolate ThNHpll/93 (P<0.05, x^2=13.283, df=1), while the susceptibility to both isolate virus strains was not significantly different in the Ae. aegypti strain from Guatemala (P>0.05, x^2=0.049, df= 1). These results suggested that the efficacy of dengue virus circulation was likely to vary according to combination of the virus strains and origin of the vector mosquitoes.
日本衛生動物学会の論文
2002-03-15