疲労と副腎皮質

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Considering mental and physical work as stressor, a study of the variation of the living body against loads through function of hypophysis and adrenal cortex in other words, on the mechanism of homeostasis has been made. As indices, uropepsin, circulatory eosinophils and 17 ketosteroid in the urine have been chosen. 1. How will the living body react by physical work? Circulatory eosinophils decrease by 30% when standing for a period of 2 hours. The circulatory eosinophils decrease by 40 to 60% on loading step test. In the later case, the recovering period is delayed. The 17 KS quantity in the urine decreases on the contrary when relaxed. No increase is observed in bycicle ergometer work or in load work of step test. 2. How will the living body react by mental work? By Kraepelin addition test, eosiophils decrease and the rate of decrease is larger as the calculation volume increases and the recovering period is delayed. A considerable regularity can be seen when the work quantity is the same. 3. How is by diurnal variation? Circulatory eosinophils increase by bed-rest. If relaxed during the morning, the deteriorating phenomenon of eosinophils does no happen. When sitting up all night, any increase during the night can not be seen. The excretion quantity of 17 KS in the urine increase by shortening the period of sleep. As to the fractions of 17 KS in the urine, not only the increase of those proper to the adrenal cortex but also that of the androgenic can be seen. The uropepsin is lowest while sleeping at night and highest just before and after starting the work in the morning, and decreases at night.
社団法人日本産業衛生学会の論文

疲労と副腎皮質

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