潜在性CCl_4中毒ウサギに及ぼすCHCl_3およびC_2H_5OHの作用

概要

論文の詳細を見る
The experiment with rabbits was to show whether CHCl_3 and C_2H_5OH were effective or not as the secondary or booster exposure of detecting inapparent industrial poisoning of CCl_4. Results were as follows. (1) There appeared no change at all in plasma GPT activities when CHCl_3 at 0.1cc/kg was administered to the normal rabbits. And after repeated administrations of a small dose of CCl_4 for 5 weeks, there was no change in GPT activities either. Receiving booster injection of a single dose of CHCl_3 at 0.1cc/kg the animals reacted to the dose by an apparent increase of plasma GPT activities this time. This result implies that CHCl_3 was effective as a secondary or booster exposure to detect the inapparent poisoning of CCl_4. (2) There was no change in plasma GPT activities when 50% C_2H_5OH at 10 cc/kg was subcutaneously injected to the chronically CCl_4 poisoned rabbits. This result meant that C_2H_5OH was not effective as a secondary or booster exposure to detect the inapparent poisoning of CCl_4. (3) The authors discussed that CCl_4 and CHCl_3 were effective as the secondary or booster exposure to detect the inapparent poisoning of CCl_4, and that the action of CCl_4 and CHCl_3 upon the inapparently poisoned animals had not yet been confirmed.
社団法人日本産業衛生学会の論文
1965-03-20