有機燐剤の神経系に及ぼす影響に関する実験的研究 : 第2報脳波, とくに深部脳波に及ぼす影響

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A study was made of the effects of intravenously administered TEEP in rabbits on the surface and deep EEG patterns from uncleus caudatus, hippcampus, thalamus dorsomedialis and the reticular formation. Effects of PAM subsequently administered to the animals on EEG and ECG were also studied. 1 Following administration of TEPP the surface EEG patterns showed an initial increase of fast waves and an initial decrease of slow weves, followed by 34 c/s regular waves. 2 Following administration of TEPP slow weves with a large amplitude decreased and 34c/s waves with a small amplitude regularly developed in the deep EEG above mentioned. 3 ECG showed a marked bradycardia. EEG showed lower voltages as ECG showed bradycardic changes. 4 Immediately after the administration of PAM the bradycardia showed a dramatic improvement revealing a gradual recovery in EEG. 5 After the reapearance of each EEG by PAM, spike discharges were observed temporarily in the EEG's on nucleus caudatus, hippcampus and the frontal surface. 6 No changes were observed in the patterns of EEG and ECG following a sole administration of 60 mg/kg of PAM. 7 Antagonistic action of PAM against TEPP was observed in the central nerve system, though it was less marked than that in the heart.