鉛吸収の血清蛋白分屑に及ぼす影響に関する研究 : 鉛作業者について

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The decrease of albumin and globulin ratio (A/G) measured by the salting-out method and the increase of γ-globulin level by the Kunkel Method in lead workers' sera were already reported by some authors in the past. The decrease of A/G ratio was observed also in the experimental lead poisoning of animals by other authors. For the purpose of making a comparative study on symptoms and the protein fraction changes due to lead absorption, an electrophoretic study on the sera of lead workers in a storage battery factory was undertaken by means of the Tiselius apparatus. Further, by the Zone electrophoresis, it was tried to determine the fraction, to which lead was supposed to be bound. The results were as follows: 1. The lead workers with slight anemia by lead absorption showed a higher level of γ-globulin percentage of serum protein than those without any symptom of anemia as well as healthy controls. 2. Lead in the serum was mainly found in the fraction which corresponds to that of albumin and there seemed to be no relation between the cause of γ-globulin percentage increase and the lead-binding capacity of protein fraction of the serum.
社団法人日本産業衛生学会の論文