^<99m>Tc-SPECTを用いたPatlak plot法による半定量的局所脳血流検査の有用性と問題点

概要

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We studied the regional cerebral blood flow on patients with severe stenotic lesions of internal carotid arteries or the Ml trunk of the middle cerebral artery by the Patlak plot method with ^<99m>Tc-SPECT, and evaluated the difference between ^<99m>Tc-ECD and ^<99m>Tc-HMPAO. The mean± SD of the regional cerebral blood flow calculated with ^<99m>Tc-ECD in the healthy side and affected side at rest was 37.2 ± 5.0 and 33.4 ± 8.3 ml/100 g/min, and that after acetazolamide administration was 42.5 ±9.2 and 36.0 + 10.9, respectively. The flow calculated with ^<99m>Tc-HMPAO in the healthy side and affected side at rest was 41.2 ± 6.7 and 37.4 ± 6.1 ml/100 g/min, and that after acetazolamide administration was 52.0 + 11.1 and 44.3 ± 9.7. Although the flow in the affected side at rest was not significantly changed after the superficial temporal artery-middle cerebral artery anastomosis, the vasoreactivity in the side showed marked improvement. This noninvasive simple method for quantitative evaluation of regional cerebral blood flow and vasoreactivity to acetazolamide is very useful in routine clinical studies.
日本脳卒中の外科学会の論文
2002-05-31