遺伝子進化のシミュレーション--遺伝子の起原に関するGC-NSF(a)仮説の証拠

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概要

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• We have previously proposed a hypothesis on the origin of genes, suggesting that genes generally originated from nonstop frames on antisense strands of GC-rich genes (GC-NSF(a)s) under the universal genetic code [Ikehara, K., et al, Nucl. Acids Res., 24,4249 (1996)]. To obtain evidence for the hypothesis, simulation of gene evolution was carried out under the six conditions for folding of polypeptide chains into appropriate three-dimensional structures using a Mycobacterium tuberculosis GC-NSF(a) (508 codons) as an ancestor gene. The results showed that the simulation well reproduces both the base compositions at three codon positions and the average amino acid compositions of extant proteins encoded by microbial genomes when a conserved region (200 codons) in simulated proteins was set at about 40%. Contrary to that, the guanine composition at the first codon position and the average amino acid compositions considerably deviated from those of extant genes and proteins when the simulation was carried out using a Borrelia burgdorferi AT-rich gene as an ancestor gene in the presence or the absence of about 40% conserved regions. These results apparently support the GC-NSF(a) hypothesis on the origin of genes which we have proposed.

• 生命の起原および進化学会の論文
• 2003-09-30

著者

• 池原 健二

  Department of Chemistry, Faculty of Science, Nara Women's University

• Ikehara Kenji

  Department Of Chemistry Faculty Of Science

• Ikehara Kenji

  Department Of Chemistry Faculty Of Science Nara Women's University

関連論文

• 遺伝子進化のシミュレーション : 遺伝子の起原に関する GC-NSF (a) 仮説の証拠
• Guanosine 5'-diphosphate 3'-diphosphate (ppGpp) Synthetic Activities on Escherichia coli SpoT Domains(Biochemistry & Molecular Biology)
• NUCLEASE ACTIVITY OF [GADV]-PEPTIDES : from "[GADV]-protein world" to "RNA-protein world"(From Molecules to Life-Like Systems & RNA World, International Symposium on Origins of Life and Astrobiology)
• A POSSIBLE EVOLUTIONARY PATHWAY OF THE GENETIC CODE DEDUCED FROM THE SNS HYPOTHESIS
• Identification of an Indispensable Amino Acid for ppGpp Synthesis of Escherichia coli SpoT Protein(Biochemistry & Molecular Biology)
• SNS HYPOTHESIS ON THE ORIGIN OF THE GENETIC CODE
• 遺伝子進化のシミュレーション--遺伝子の起原に関するGC-NSF(a)仮説の証拠
• The [GADV]-protein world hypothesis on the origin of life(Chemical Evolution, International Symposium on Origins of Life and Astrobiology)

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