Effect of Lauric Acid on Cell Division, Macromolecular Synthesis and Membrane Lipid Organization in Escherichia coli
スポンサーリンク
概要
- 論文の詳細を見る
Lauric acid (1mg/ml) sharply suppressed the cell division of an acrA mutant strain of Escherichia coli K12. However, the wild type acrA+ strain was resistant to the fatty acid. Capric acid and myristic acid were not so toxic. Lauric acid inhibited both DNA and protein synthesis of the acrA mutant strain, with the former being more sensitive than the latter. On the other hand, DNA polymerase activity of toluene-treated cells was stimulated rather than inhibited by the presence of 1mg/ml of lauric acid. Fatty acid composition of phospholipids in the inner membrane was largely altered by the addition of lauric acid. These results suggest that addition of lauric acid to the medium causes a disorganization of the membrane lipids in the acrA mutant cell and activities of DNA polymerase and other intramembranous enzymes are consequently inhibited.
- 日本植物生理学会の論文
著者
-
Hase Atsushi
Biological Institute Faculty Of Science Konan University:(present)osaka City Institute Of Public Hea
-
Hase Atsushi
Biological Institute Faculty Of Science Konan University
-
Nakamura Hakobu
Biological Institute Faculty Of Science Konan University
関連論文
- Effects of Acriflavine on the Formation of the Plasma Membrane of Escherichia coli
- 大腸菌の生成速度に影響を及ぼすアクリフラビン感受性変異〔英文〕
- Increased Resistance to Acriflavine by Amplification of the acrA Gene of Escherichia coli K-12
- A Role for the acrA Gene in the Protection of Escherichia coli Cells against Excess Sodium
- 大腸菌の遺伝的組換に及ぼす,ストレプトマイシンの存在における,acrA変異の影響〔英文〕
- 大腸菌のアクリジンおよび塩基性色素感性株の糖利用診断(速報)〔英文〕
- 酵母のカドミウム耐性の研究〔英文〕-6-
- A Plasma Membrane Mutation acr A in Escherichia coli
- Effect of Lauric Acid on Cell Division, Macromolecular Synthesis and Membrane Lipid Organization in Escherichia coli
- Genetic Basis of Evolution
- 大腸菌acrA変異株における多剤耐性因子の安定性について〔英文〕