Synthesis of Unnatural 1-Methyl-2-quinolone Derivatives

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概要

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• Unnatural 1-methyl-2-quinolone derivatives were synthesized by regioselective C-C bond formation. When 1-methyl-3, 6, 8-trinitro-2-quinolone (TNQ) was treated with enamines, nucleophilic addition readily occurred at the 4-position, and succeeding hydrolysis of enamine moiety followed by elimination of nitrous acid furnished 4-acylmethyl-1-methyl-6, 8-dinitro-2-quinolones. The same products could be prepared by the reaction of TNQ with ketones in the presence of triethylamine. The present reaction enabled the introduction of various kinds of acylmethyl groups substituted with alkyl, aryl or hetaryl groups.

• 公益社団法人日本薬学会の論文
• 2004-11-01

著者

• TOHDA Yasuo

  Division of Natural Science, Osaka Kyoiku University

• Ariga Masahiro

  Osaka Kyoiku University

• Tohda Y

  Division Of Natural Science Osaka Kyoiku University

• ASAHARA Motoki

  Department of Chemistry, Osaka Kyoiku University

• KATAYAMA Taku

  Department of Chemistry, Osaka Kyoiku University

• TOHDA Yasuo

  Department of Chemistry, Osaka Kyoiku University

• NISHIWAKI Nagatoshi

  Department of Chemistry, Osaka Kyoiku University

• ARIGA Masahiro

  Department of Chemistry, Osaka Kyoiku University

• Ariga Masahiro

  Department Of Chemistry Osaka Kyoiku University

• NISHIWAKI Nagatoshi

  Anan National College of Technology

• Nishiwaki Nagatoshi

  Department Of Chemistry Osaka Kyoiku University

• Katayama Taku

  Department Of Chemistry Osaka Kyoiku University

• Ariga Masahiro

  Dep. Of Chemistry Osaka Kyoiku Univ.

• Nishiwaki Nagatoshi

  Center For Collaborative Res. Anan National Coll. Of Technol.

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