A One-Pot Synthesis of 3-Aminopyridines

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概要

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• The reaction of N-(cyanophenylmethyl)acylamides (1) with olefins (2) in the presence of trifluoroacetic acid gave the corresponding 3-amino-2-phenylpyridines (3) in good yields. Similar reaction of ethyl 2-acylamino-2-cyanoacetates (4) with olefins in the presence of trifluoroacetic acid afforded ethyl 3-aminopyridine-2-carboxylates (5) in a one-pot procedure. The mechanism of the reaction is discussed.

• 公益社団法人日本薬学会の論文
• 1983-10-25

著者

• 前田 博

  Research Institute of Drug Safety, Setsunan University

• 嶋田 定勝

  Production Technology Research Laboratories Daiichi Seiyaku Co. Ltd.

• 前田 博

  Research Laboratories Of Production Technology Daiichi Seiyaku Co. Ltd.

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• A Convenient Synthesis of Pyridoxine
• Intramolecular Diels-Alder Reaction of Alkenyl Oxazole-5-carbamates and N-Alkenyl-oxazole-5-carboxamides
• A One-Pot Synthesis of 3-Aminopyridines

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