Conversion of Cathepsin E to Enzymatic Unstable Form in Gastric Cancer Cells
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概要
- 論文の詳細を見る
A new acid proteinase in human gastric cancer, named medium moving proteinase (Med. P), was found also in a gastric cancer transplanted into nude mouse. However, Med. P disappeared when the samples prepared from gastric cancer tissues were left for over 4 weeks at -80℃, whereas the activity of cathepsin E (CE) increased. When these samples were reduced by dithiothreitol (DTT), Med. P appeared again and the CE activity decreased. These phenomena, revealed by electrophoretic analyses, indicated that Med. P is a monomeric form of CE (mono-CE). At weakly alkaline pH and after heating, mono-CE appeared to be more unstable than CE. These results indicated that CE assume an enzymatically unstable monomeric form in cancer cells.
- 社団法人日本薬学会の論文
- 1995-11-15
著者
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矢野 喬史
栄研化学
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矢野 喬史
Eiken Chemical Co. Ltd.
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森川 惇二
Eiken Chemical Co. Ltd.
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古川 智子
(株) エスアールエル医科学分析センター
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青木 隆
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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高崎 智子
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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古川 智子
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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渡部 博之
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkai
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渡部 博之
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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高崎 智子
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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吉川 智子
和歌山県立医科大学 第一外科
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青木 隆
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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