Cyclic Guanidines. X. Synthesis of 2-(2,2-Disubstituted Ethenyl-and Ethyl)-2-imidazolines as Potent Hypoglycemics

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概要

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• 2-(2,2-Disubstituted ethenyl-and ethyl)-2-imidazoline derivatives (11,14) were prepared by direct cyclization of active intermediates, 3,3-disubstituted acrylimidic ethyl esters (9,10), with ethylenediamine. The stereoisomers, (Z)-and (E)-3-phenyl-3-pyridylacrylic acid esters (6c-e), nitriles (7c-e) and amides (8c-e), as well as (Z)-and (E)-3-phenyl-3-pyridylacrylimidic acid esters (10c-e), and (Z)-and (E)-2-(2-pyridylethenyl)-2-imidazolines (11c-e), were isolated. Their structures are discussed. Compounds 11 and 14 showed potent hypoglycemic activity.

• 公益社団法人日本薬学会の論文
• 1980-05-25

著者

• 石川 文美

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 石川 文美

  Research Institute Daiichi Seiyaku Co. Ltd.

関連論文

• Cyclic Guanidines. IX. Synthesis of 2-Amino-3,4-dihydroquinazolines as Blood Platelet Aggregation Inhibitors
• Cyclic Guanidines. X. Synthesis of 2-(2,2-Disubstituted Ethenyl-and Ethyl)-2-imidazolines as Potent Hypoglycemics

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