Decomposition of Dithiocarbamates. VII. The Decomposition of N-Monosubstituted Dithiocarbamic Acid in Alkaline Solutions

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概要

• 論文の詳細を見る

• The decompositions of five N-monosubstituted dithiocarbamic acids (I) to isothiocyanate (V) and bisulfide ion were kinetically investigated over a wide range of alkali concentrations from pH to acidity function regions. The experimental first-order rate constants are proportional to the mole fraction of the anion form of I (II). The pH-rate profiles fit with an equation k_<obs>=k [H+]/(K_<III>+[H+]) (eq. 4). The decomposition proceeds directly via II but not via III, conjugate base of II. The reaction was retarded by the reverse reaction of V with bisulfide ion. The effects of the initial concentration of I and bisulfide ion on the rate are also discussed.

• 公益社団法人日本薬学会の論文
• 1973-06-25

著者

• 徳山 幹治

  Production Department, Shionogi and Co., Ltd.

• 前田 孝

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 鷹見 文隆

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 徳山 幹治

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 若原 繁

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 徳山 幹治

  Production Department Shionogi And Co. Ltd.

• 若原 繁

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 鷹見 文隆

  Shionogi Research Laboratory Shionogi & Co. Ltd.

関連論文

• Reactions of 2-Formyl-3-methoxypropionitrile Derivatives as Electrophilic Reagent
• Decomposition of Dithiocarbamates. IX. The Effect of Carbon Disulfide on the Decomposition of N-Monosubstituted Dithiocarbamic Acids
• Decomposition of Dithiocarbamates. VIII. The Decomposition Mechanism of [(4-Amino-2-methyl-5-pyrimidinyl) methyl] -dithiocarbamic Acid and Related Compounds in Alkaline Solutions
• Decomposition of Dithiocarbamates. VII. The Decomposition of N-Monosubstituted Dithiocarbamic Acid in Alkaline Solutions
• Decomposition of Dithiocarbamates. VI. The Decomposition of N-Monosubstituted Dithiocarbamic Acids in Acidic Solutions
• Decomposition of Dithiocarbamates. V. The Dissociations of N-Monosubstituted Dithiocarbamic Acids in strongly Acidic and Alkaline Solutions
• Decomposition of Dithiocarbamates in weakly Acidic Solutions
• Acetalation Mechanism of 2-Formyl-3-methoxypropionitrile in Methanolic Hydrogen Chloride

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