Three Types of Membranous ATPase on Rat Liver Lysosomes

概要

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At least three types of vanadate-insensitive membranous ATPase were idenfied on rat liver lysosomes : bafilomycin A_-1sensitive Mg^<2+>-ATPase (H^+-ATPase), N-ethylmaleimide (NEM)-sensitive but bafilomycin A_1-insensitive Mg^<2+>-ATPase (ATPase I), and NEM-insensitive Ca^<2+>/Mg^<2+>-ATPase (ATPase II). They showed different sensitivity to chemicals and ions with apparent molecular masses of 700-800,500-650,and 360 kDa, respectively. Of these membranous ATPase, H^+-ATPase seemed to constitute only one tenth of the ATPase activity on rat liver lysosomes and to be the only ATPase that exposed its active site to the cytoplasmic side of the lysosomal membranes.
社団法人日本薬学会の論文
1992-10-25