Effects of Streptozotocin and of Glucose Loading on Activities of Lysosomal Thiol Proteinases in Rat Pancreatic Tissue

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概要

• 論文の詳細を見る

• Changes in the activities of lysosomal thiol proteinases and their endogenous inhibitors were examined in the rat pancreatic tissue. Imposed stress such as fasting affected the activities of cathepsins B and H but not those of their endogenous inhibitors. However, changes in the activities of cathepsins B and H are closely related to changes in the activities of their inhibitors. During the phase of hypoglycemia and hyperinsulinemia induced by streptozotocin, there were increments in the activities of cathepsins B and H and their endogenous inhibitors. These changes were not related to increases in the levels of serum insulin but rather to pathological changes in the pancreas.

• 公益社団法人日本薬学会の論文
• 1988-03-25

著者

• 食見 忠弘

  Department of Pharmacology

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