Effect of Biliary Drainage on Bile Acid Conjugation with Taurine in Vitamin B_6-Deficient Rats

概要

論文の詳細を見る
Feeding of a synthetic, vitamin B_6-deficient diet for 7 weeks caused a marked increase in the ratio of glycine- to taurine-conjugated bile acids in the bile of rats. The highly elevated ratio, however, was reduced spontaneously by the elapsing time of biliary drainage, and the decrease in the ratio was accelerated by a subcutaneous administration of 2 g/kg of taurine. An intravenous injection of 5 mg/kg of sodium deoxycholate caused a temporary increase in the biliary secretion of taurodeoxycholic acid in both groups of normal and vitamin B_6-deficient animals, and taurine loading prior to the deoxycholate-injection further augmented the increased secretion of this taurine-conjugated bile acid fraction. The glycodeoxycholic acid secretion in vitamin B_6-deficient rats was not increased significantly after the deoxycholate-injection.
公益社団法人日本薬学会の論文
1974-05-25