5,5-Disubstituted 2-Thiohydantoin類のArylsulfonyl化反応
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概要
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Reaction of 5,5-diphenyl-2-thiohydantoin (I) with benzenesulfonyl chloride in the presence of 1.0 equimolar amount of triethylamine resulted solely in the formation of 3-benzenesulfonyl-5,5-diphenyl-2-thiohydantoin (III) in a poor yield, while the presence of exces samine gave solely bis (1-benzenesulfonyl-4,4-diphenyl-5-oxo-2-imidazolin-2-yl) disulfide (IV) in 50% yield. The formation of IV from I was examined and it was found that the reaction involves ring opening of III to a novel intermediate, triethylammonium salt of N-benzenesulfonyl-2-isothiocyanato-2,2-diphenylacetamide (VI).
- 公益社団法人日本薬学会の論文
- 1970-11-25
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