ベンツイミダゾール誘導体の抗ウイルス性(第2報) : ビスベンツイミダゾール誘導体

概要

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The inhibitory effect of 1,2-bis(2-benzimidazolyl) ethane and 1,2-bis (2-benzimidazolyl)-ethanol derivatives on poliovirus and adenovirus replication was investigated by the tube method. Among the compounds tested, 1,2-bis (5-(or 6-) chloro-2-benzimidazolyl) ethane (III), 1,2-bis(5-(or 6-) methoxy-2-benzimidazolyl) ethane (V), 1,2-bis (5-(or 6-) methyl-2-benzimidazolyl) ethanol (VII), and 1,2-bis (5-(or 6-) methoxy-2-benzimidazolyl) ethanol (IX) exerted a clear inhibition of the cytophathic effect of poliovirus. In the concentration of 10^<-3>-10^<-5> mole, V and IX showed complete inhibition of the plaque formation by poliovirus, and indicated that the inhibition index, which is expressed as the logarithmic difference of TCID_<50>/ml in treated and untreated, was about 7.0. This inhibitory effect is greater than that of 2-(α-hydroxybenzyl) benzimidazole. These compounds also show almost complete block of the reproduction mechanism in intracellular viral growth of poliovirus.
公益社団法人日本薬学会の論文
1970-10-25