Relationship among Tissue Plasminogen Activator, Sperm and Protein in Human Semen

概要

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We measured the sperm count, and protein and tissue plasminogen activator (t-PA) levels in human semen samples from 13 individuals (aged 28 to 40 years). The mean volume of the human semen samples was 4.1±1.6ml (mean± SD), ranging from 1.8 to 6.6ml. The average protein concentration was 22.3±13.6g/l semen, but the values showed a wide distribution ranging from 7.2 to 59.4g/l semen. The t-PA antigen concentration and total amount of t-PA antigen in the human semen samples were 0.466±391mg/l semen and 2.194±2.531 μg/semen sample, respectively, and they showed a distribution ranging from 0.145 to 1.650mg/l semen and 0.370 to 9.900 μg/semen sample, respectively. Strong correlations were observed between the total t-PA antigen amount and total sperm count or total protein amount (p<0.01), and a good correlation was also observed between t-PA antigen concentration and sperm count (p <0.05). However, the protein concentration and t-PA antigen concentration showed a weak correlation.
Japan Society of Clinical Chemistryの論文