Isoquinoline系化合物の制癌性に関する研究(第4報) : 1-Alkyl置換isoquinoline誘導体のEhrlich腹水性細胞およびマウス正常肝細胞のエネルギー生産系におよぼす影響

概要

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Effect of two 1-alkyl substituted isoquinoline derivatives, having antitumor activities, on energy-generating system of Ehrlich ascites carcinoma cells and normal hepatic cells was investigated. 1-(2-Methylbutyl)-3-methyl-6,7-methylenedioxyisoquinoline hydrochloride (B-15) and 1-(1,1-dimethylpropyl)-3-methyl-6,7-methylenedioxyisoquinoline hydrochloride (B-19) were strong inhibitiors of dehydrogenase activities of these cells in the medium free from any substrate. However, when glucose was used as a substrate, B-19 was stronger inhibitor of dehydrogenase activities of Ehrlich ascites carcinoma cells than B-15. Both compounds showed marked inhibitory effect on endogenous respiration of the cells, and especially a selective inhibitory activity against Ehrlich ascites carconoma cells was observed with B-15. However, oxygen consumption of Ehrlich ascites carcinoma cells respiring in the presence of glucose was stimulated with an optimum concentration of B-15,whereas anaerobic glycolysis of the cells was inhibited by these compounds when the production of lactate was measured. From these results, it was suggested that these compounds might have a different effect on the respiration of the cells.
公益社団法人日本薬学会の論文
1969-03-25