エリスロマイシン錠のヒトでのBioavailabilityと副作用との関係

概要

論文の詳細を見る
We studied the relationship between bioavailability and incidence of side reaction of commercial erythromycine tablets. Bioavailability of the preparations was determined by measuring area under the serum concentration of the drug-time curve (AUC), peak height and time to attain the peak in serum concentration. Frequency of appearance of side reaction was surveyed by questionaire to each volunteer. Five kinds of commercial tablets were administered to groups of 20 healthy female volunteers, and bioavailability and frequency of side reaction were investigated. A correlation between the frequency of side reaction and relative AUC, set as 100% in the case of C product, was observed. Four volunteers complained of side reaction in the case of C product, while in the case of A product (relative AUC 4%), and nobody complained of side reaction. These relationships were also observed between the frequency side reaction and the peak height and/or the time to attain the peak of drug concentration. When test tablets containing an equivalent amount of the drug and coated with various enteric coating substances of different dissolution pH were administered to the same volunteers, the same inclination was noted. Average in the peak height of serum concentration was higher in volunteers who complained of gastralgia than in volunteers who did not complain of any side reaction.
社団法人日本薬学会の論文
1979-03-25