市販クロラムフェニコール錠の人におけるBioavailabilityについての研究

概要

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Since there are few reports on the bioavailability of various commercial pharmaceutics sold on Japanese markets in human beings, some experiments were carried out on commercial chloramphenicol tablets (250 mg/tablet). Products from 16 firms were examined for the antibiotic content and disintegration time, and five brands showing different values were selected to measure their serum level in humans. A total of 25 healthy females were selected for each brand and assigned by the Latin square method. Each person was made to take two tablets (500 mg) at a time, and serum level of chloramphenicol was measured 1,2,3,and 6 hr later. Values were also measured after 6,8,10,and 12 hr for three of these brands. Consequently, the serum level was measured in a total of 134 persons. Average values of maximum serum level ratio were 100,89,86,72,and 55% for the five brands, and the average values of area ratio below the serum level curves were 100,92,91,64,and 46%. These differences in the values are considered to be due to the difference in the manufacturing technology, especially in the use of additives.
社団法人日本薬学会の論文
1975-05-25