3-(Tetrahydro-2-furanyl)-5-fluorouracilの合成

スポンサーリンク

概要

• 論文の詳細を見る

• Synthesis of 3-(tetrahydro-2-furanyl)-5-fluorouracil (3-Thf-FU) (III), which has been found to be a metabolic intermediate of 1,3-bis (tetrahydro-2-furanyl)-5-fluorouracil (Thf_2-FU) and an effective antitumor agent, is reported. 1-Alkane- or 1-arene-sulfonyl-5-fluorouracil (I) was trimethylsilylated by treatment with N, O-bis (trimethylsilyl) acetamide and treated with 2-acetoxytetrahydrofuran in the presence of stannic chloride to give 1-alkane- or 1-arene-sulfonyl-3-(tetrahydro-2-furanyl)-5-fluorouracil (II). III was obtained by deblocking of II with methanolic ammonia.

• 社団法人日本薬学会の論文
• 1978-11-25

著者

• 山下 純一

  Hanno Research Center, Taiho Pharmaceutical Co., Ltd.,

• 山下 純一

  Hanno Research Center Taiho Pharmaceutical Co. Ltd.

• 安本 三治

  Kodama Institute, Taiho Pharmaceutical Co., Ltd.,

• 安本 三治

  大鵬薬品工業株式会社技術研究部

• 山下 純一

  大鵬薬品工業株式会社技術研究部

• 橋本 貞夫

  大鵬薬品工業株式会社技術研究部

• 安本 三治

  Kodama Institute Taiho Pharmaceutical Co. Ltd.

• 山下 純一

  大鵬薬品工業(株)がん研究所

• 橋本 貞夫

  Research Institute Taiho Pharmaceutical Co. Ltd.

• 橋本 貞夫

  大鵬薬品工業 (株) 技術本部研究部

関連論文

• Antitumor Agents. II : Regio- and Stereospecific Syntheses of 1-β-Alkyl-1-desoxypodophyllotoxin Derivatives and Biological Activity
• Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Studies on Antitumor Agents. VII. Antitumor Activities of O-Alkoxyalkyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. VI. Syntheses and Antitumor Activities of Acyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Tetrahydrofuryl-5-fluorouracils. IV. Mode of Reaction of 5-Fluorouracil with 2-Acetoxytetrahydrofuran
• Studies on Antitumor Agents. V. Syntheses and Antitumor Activities of 5-Fluorouracil Derivatives
• Studies on Antitumor Agents. IV. Syntheses and Antitumor Activities of Compounds related to 1-(Tetrahydro-2-furanyl)-5-fluorouracil Metabolites
• 3-(Tetrahydro-2-furanyl)-5-fluorouracilの合成
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Studies on Antitumor Agents. VII. Antitumor Activities of O-Alkoxyalkyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. VI. Syntheses and Antitumor Activities of Acyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Studies on Antitumor Agents. VII. Antitumor Activities of O-Alkoxyalkyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. VI. Syntheses and Antitumor Activities of Acyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Studies on Antitumor Agents. VII. Antitumor Activities of O-Alkoxyalkyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. VI. Syntheses and Antitumor Activities of Acyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Studies on Antitumor Agents. VII. Antitumor Activities of O-Alkoxyalkyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Antitumor Agents. VI. Syntheses and Antitumor Activities of Acyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine(Medicinal Chemistry,Chemical)
• Studies on Hypolipidemic Agents. II. : Synthesis of 1-Arenesulfonyloxy-2-alkanone Derivatives as Potent Esterase Inhibitors and Hypolipidemic Agents
• Studies of Hypolipidemic Agents. I. : Syntheses and Hypolipidemic Activities of 1-Substituted 2-Alkanone Derivatives
• フトラフール® (一般名 : テガフール) について
• 含フッ素医薬品一覧

もっと見る 閉じる

スポンサーリンク