Studies on Tetrahydrofuryl-5-fluorouracils. IV. Mode of Reaction of 5-Fluorouracil with 2-Acetoxytetrahydrofuran
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概要
- 論文の詳細を見る
The mechanism of the condensation of 5-fluorouracil and 2-acetoxytetrahydrofuran (3), giving 1-(tetrahydro-2-furyl)-5-fluorouracil, was studied. An equilibrium between 2-acetoxytetrahydrofuran (3) and 2,3-dihydrofuran (4) was observed at 120-170℃ in dimethylformamide. It was found by the use of 1,3-dideuterio-5-fluorouracil that the condensation of 5-fluorouracil with 3 occurred both by direct substitution and by the formation of 4 from 3 followed by addition of the uracil to it. The contribution of the latter path increased with increase of the reaction temperature.
- 社団法人日本薬学会の論文
- 1983-11-25
著者
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山下 純一
Hanno Research Center, Taiho Pharmaceutical Co., Ltd.,
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山下 純一
Hanno Research Center Taiho Pharmaceutical Co. Ltd.
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安本 三治
Kodama Institute, Taiho Pharmaceutical Co., Ltd.,
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山下 純一
Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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安本 三治
Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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橋本 貞夫
Research Laboratory, Taiho Pharmaceutical Co., Ltd.
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安本 三治
Kodama Institute Taiho Pharmaceutical Co. Ltd.
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橋本 貞夫
Research Institute Taiho Pharmaceutical Co. Ltd.
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