鎮痛薬に関する研究(第4報)5-Aminomethylsalicylic Acidのウサギおよびラットにおける体内動態

概要

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The metabolic fate of 5-aminomethylsalicylic acid (AMS), a new analgesic agent, was examined in rabbits and rats. The blood level of AMS reached a maximum 1 hr after its subcutaneous injection in rabbits. The blood level was approximately 10% of the initial level 5 hr after the intravenous injection in rabbits, and about 90% of the given dose was excreted in urine during this period. AMS was found to be bound to plasma protein rather loosely compared to other salicylate compounds. The urinary excretion of AMS and its metabolites in rabbits was 50% in 3 hr and about 100% in 9 hr after the subcutaneous injection of AMS. The major metabolites in urine were free AMS, its glycine conjugate, and 4-hydroxyisophthalic acid, an ouidation product of AMS, which amounted to 70,11,and 19% of the administered dose, respectively. The urinary excretion pattern in rats was similar to that in rabits.
公益社団法人日本薬学会の論文
1977-04-25