鎮痛薬に関する研究(第5報^<1)>)5-Aminomethylsalicylic Acidの抗炎症作用機序の研究

概要

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The mechanism of anti-inflammatory action of 5-aminomethylsalicylic acid (AMS) was investigated. (1) AMS as well as salicylate showed more significant inhibition of the leucocyte migration, in normal rats than in adrenalectomized rats. AMS (100 mg/kg, i.p.) inhibited it by 50.4% in normal rats and 28.7% in adrenalectomized rats. (2) AMS decreased the ascorbic acid level in the adrenals by 22.8 and 52.3% at the dose of 100 and 200 mg/kg, i.p., respectively. (3) Although a single treatment with 100 mg/kg, i.p., was ineffective, 7-day administration of AMS (50 mg/kg, i.p.) increased significantly the rate of corticosterone release from isolated rat adrenals (49.0%) and its blood level (44.0%). (4) Oxygen uptake and glucose consumption by isolated rabbit leucocytes were markedly increased with AMS (15 mg/dl), while these effects were not observed in the system with an addition of E.coli. (5) AMS (2.4×10^<-5> M) inhibited markedly the respiration and coupled phosphorylation in the cyclophorase system from brain and liver. (6) With 7-day administration of AMS (50 mg/kg, i.p.), the hemogram of rats was not affected. (7) AMS inhibited the heat coagulation of bovine serum albumin by 6.8 and 13.6% at the concentration of 15 and 30 mg/dl, respectively.
公益社団法人日本薬学会の論文
1977-03-25